Sucralfate and Honey in Burn Wound Healing: An Article Review
DOI:
https://doi.org/10.25251/yjadqx70Keywords:
Sucralfate, Honey, Burns, Wound HealingAbstract
Introduction : Several studies stated that sucralfate and honey topically promote wound healing process. Sucralfate has been used for stomatitis, excoriation in perianal and peristomal, ulcers, and burn wounds. Honey as a food which is taken orally, is also used topically for several kind of wounds including burn wounds. However, there is no study reviewing sucralfate and honey in burn wounds.
Method : Literature review was conducted from 1st until 6th of June 2022 using the terms of “honey”, “sucralfate”, “burns” and “wound healing”. Pubmed, Cohrane, Science Direct, Scopus, and Google Scholar were the online data bases we used. We identified eight studies, three trials evaluated the effects of sucralfate in burn wounds and five trials evaluated the effects of honey in burn wounds.
Result : 3 Randomized Controlled Trials (RTCs) (n=170) about the effects of sucralfate and 5 RCTs (n=474) reported the effects of honey in burn wounds. Both Sucralfate and Honey group had similar wound healing duration around 18 days and had early sign of wound healing by day 7. Honey has faster complete wound healing compared to sucralfate by day 21. Honey has remarkable antimicrobial effect within one hour. No side effects were reported in both trials. Both honey and sucralfate reduce the necessity for skin grafting.
Conclusion: Both sucralfate and honey have similar rapid re-epithelization in burn wounds, but honey has faster complete wound healing by day 21. Both has similar antimicrobial effect, no side effects, and reduce the necessity for skin grafting.
References
Lumintang L, Adnyana MS, Riasa INP, Asmarajaya AAGN, Hamid AR, Sanjaya H. A Systematic Review: Topical Sucralfate for Burn Wound. Open Access Maced J Med Sci [Internet]. 2021 Nov. 3 [cited 2024 Jan. 31];9(F):516-22. Available from: https://oamjms.eu/index.php/mjms/article/view/6253
Aziz Z, Abdul Rasool Hassan B. The effects of honey compared to silver sulfadiazine for the treatment of burns: A systematic review of randomized controlled trials. Burns. 2017 Feb;43(1):50-57. doi: 10.1016/j.burns.2016.07.004. Epub 2016 Aug 28. PMID: 27576926.
Jonathan W. White. Honey. Advances in Food Research. 1978; 24. doi.org/10.1016/S0065-2628(08)60160-3.
Moore OA, Smith LA, Campbell F, Seers K, McQuay HJ, Moore RA. Systematic review of the use of honey as a wound dressing. BMC Complement Altern Med. 2001;1:2. doi: 10.1186/1472-6882-1-2. Epub 2001 Jun 4. PMID: 11405898; PMCID: PMC32305.
Banati A, Chowdhury SR, Mazumder S. Topical use of Sucralfate Cream in second and third degree burns. Burns. 2001 Aug;27(5):465-9.
Godhi AS, Ram P, Powar R. Efficacy of topical sucralfate vERSUs silver sulfadiazine in the management of burns: A 1-year randomized controlled trial. J West Afr Coll Surg. 2017 Jan-Mar;7(1):57-70. PMID: 29951455; PMCID: PMC6018035.
Koshariya, Mahim et al. “Role of topical Sucralfate in healing of burn wounds.” International Surgery Journal (2018): n. pag.
Subrahmanyam M. A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Burns. 1998 Mar;24(2):157-61. doi: 10.1016/s0305-4179(97)00113-7. PMID: 9625243.
Subrahmanyam M. Topical application of honey in treatment of burns. Br J Surg. 1991 Apr;78(4):497-8. doi: 10.1002/bjs.1800780435. PMID: 2032114.
Subrahmanyam M. Honey impregnated gauze versus polyurethane film (OpSite) in the treatment of burns--a prospective randomised study. Br J Plast Surg. 1993 Jun;46(4):322-3. doi: 10.1016/0007-1226(93)90012-z. PMID: 8330089.
Baghel PS, Shukla S, Mathur RK, Randa R. A comparative study to evaluate the effect of honey dressing and silver sulfadiazene dressing on wound healing in burn patients. Indian J Plast Surg. 2009 Jul;42(2):176-81. doi: 10.4103/0970-0358.59276. PMID: 20368852; PMCID: PMC2845359.
Malik KI, Malik MA, Aslam A. Honey compared with silver sulphadiazine in the treatment of superficial partial-thickness burns. Int Wound J. 2010 Oct;7(5):413-7. doi: 10.1111/j.1742-481X.2010.00717.x. PMID: 20649832; PMCID: PMC7951523
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