Multiple Lower Eyelid Nodules In Breast Cancer Patient With History Of Dermal Fillers: A Case Report
DOI:
https://doi.org/10.14228/jpr.v6i2.289Keywords:
lower eyelid nodules; breast cancer; dermal filler; metastasisAbstract
Background: Dermal filler injections have been associated with several complications, including migration to other areas and forming nodules due to the presence of foreign bodies or granulomatous reactions may develop, which encapsulates the filler. Fillers might also be associated with malignancy. The presence of such complications must be removed with reconstructive surgery.
Methods: We present a case of breast cancer patient with a history of dermal filler injection to the lower eyelid. The nodules in the lower eyelid was surgically removed, and the lower eyelid, particularly the muscle, was reconstructed to provide a good cosmetic result. The nodules were also pathologically examined to confirm the diagnosis. Reconstruction of the lower eyelid was conducted with care by noting the aesthetic aspects.
Results: A local muscle flap was easy to harvest and handle, and provided good results. It is also important to consider malignancy to treat the patient thoroughly. The pathology examination confirmed the diagnosis of metastasis. This case is unique because the nodules developed in the patient may be associated with metastasis of the cancer or the dermal filler injection.
Conclusion: Our reconstruction technique leads to a good cosmetic result. There are no sign of complications and recurrence at 3 months following the procedure.
References
2. Lee S, Yen MT. Nonsurgical Rejuvenation of the Eyelids with Hyaluronic Acid Gel Injections. Semin Plast Surg. 2017 Feb;31(1):17-21.
3. Artzi O, Loizides C, Verner I, Landau M. Resistant and recurrent late reaction to hyaluronic acid-based gel. Dermatol Surg. 2016;42:31–37.
4. Shalapour S, Karin M. Immmunity, inflammation, and cancer: an eternal fight between good and evil. J Clin Invest. 2015 Sep;125(9):3347-55.
5. Bhojani-Lynch T. Late-Onset Inflammatory Response to Hyaluronic Acid Dermal Fillers. Plast Reconstr Surg Glob Open. 2017 Dec;22;5(12):e1532.
6. Haneke E. Managing complications of llers: Rare and not-so-rare. J Cutan Aesthet Surg. 2015;8:198-210.
7. Alsaad SM, Fabi SG, Goldman MP. Granulomatous Reaction to Hyaluronic Acid: A Case Series and Review of the Literature. Dermatol Surg. 2012;38:271–276
8. Goodier MA, Jordan JR. Metastatic Breast Cancer to the Lower Eyelid. Laryngoscope. 2010;120 Suppl 4:S129.
9. Riley FC. Metastatic tumors of the eyelids. Am J Ophthalmol. 1970;69(2):259-264.
10. Mansour AM, Hidayat AA. Metastatic eye lid disease. Ophthalmology. 1987;94(6): 667-670.
11. Mayer JE, Maurer MA, Nguyen HT. Diffuse cutaneous breast cancer metastases resembling subcutaneous nodules with no surface changes. Cutis. 2018 Mar;101(3):219-223.
12. Lookingbill DP, Spangler N, Helm KF. Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol. 1993;29(2, part 1):228-236.
13. Edwards PC, Fantasia JE. Review of long-term adverse effects associated with the use of chemically-modified animal and nonanimal source hyaluronic acid dermal fillers. Clin Interv Aging. 2007;2(4):509-19.
14. Stern R. 2003. Devising a pathway for hyaluronan catabolism: are we there yet? Glycobiology, 13:r105–15.
15. Fakhari A, Berkland C. Applications and emerging trends of hyaluronic acid in tissue engineering, as a dermal filler and in osteoarthritis treatment. Acta Biomater. 2013 Jul;9(7):7081-92.
16. Hill A, McFarlane S, Johnston PG, et al. The emerging role of CD44 in regulating skeletal micrometastasis. Cancer Letts. 2006;237:1–9.
17. Coussens LM, Werb Z. Inflammation and Cancer. Nature. 2002 Dec 19; 420(6917): 860–867.
18. Peinado H, Lavotshkin S, Lyden D. The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts. Semin Cancer Biol. 2011;21, 139–146.
19. Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell. 2010;141, 39–51.
20. Codner MA, Wolfli JN, Anzarut A. Primary Transcutaneous Lower Blepharoplasty with Routine Lateral Canthal Support:A Comprehensive 10-Year Review. Plast Reconstr Surg. 2008 Jan;121(1):241-50.
21. Jacono AA, Moskowitz B. Transconjunctival versus Transcutaneous Approach in Upper and Lower Blepharoplasty. Facial Plast Surg. 2001 Feb;17(1):21-8.
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