Published : 6 March 2024

Sucralfate and Honey in Burn Wound Healing: An Article Review

  • Aditya Wardhana
  • Nadya Farhana

Volume 11, Issue 1, (2024) Jurnal Plastik Rekonstruksi | Pages : 22-27

DOI: 10.14228/jprjournal.v11i1.371   Reader : 24 times PDF Download : 5 times

Abstract

Introduction : Several studies stated that sucralfate and honey topically promote wound healing process. Sucralfate has been used for stomatitis, excoriation in perianal and peristomal, ulcers, and burn wounds. Honey as a food which is taken orally, is also used topically for several kind of wounds including burn wounds. However, there is no study reviewing sucralfate and honey in burn wounds.
Method : Literature review was conducted from 1st until 6th of June 2022 using the terms of “honey”, “sucralfate”, “burns” and “wound healing”. Pubmed, Cohrane, Science Direct, Scopus, and Google Scholar were the online data bases we used. We identified eight studies, three trials evaluated the effects of sucralfate in burn wounds and five trials evaluated the effects of honey in burn wounds.
Result : 3 Randomized Controlled Trials (RTCs) (n=170) about the effects of sucralfate and 5 RCTs (n=474) reported the effects of honey in burn wounds. Both Sucralfate and Honey group had similar wound healing duration around 18 days and had early sign of wound healing by day 7. Honey has faster complete wound healing compared to sucralfate by day 21. Honey has remarkable antimicrobial effect within one hour. No side effects were reported in both trials. Both honey and sucralfate reduce the necessity for skin grafting.
Conclusion: Both sucralfate and honey have similar rapid re-epithelization in burn wounds, but honey has faster complete wound healing by day 21. Both has similar antimicrobial effect, no side effects, and reduce the necessity for skin grafting.

Data Availability

All data generated during this study are included in this published article [and its supplementary information files].

References

  1. Lumintang L, Adnyana MS, Riasa INP, Asmarajaya AAGN, Hamid AR, Sanjaya H. A Systematic Review: Topical Sucralfate for Burn Wound. Open Access Maced J Med Sci [Internet]. 2021 Nov. 3 [cited 2024 Jan. 31];9(F):516-22. Available from: https://oamjms.eu/index.php/mjms/article/view/6253
  2. Aziz Z, Abdul Rasool Hassan B. The effects of honey compared to silver sulfadiazine for the treatment of burns: A systematic review of randomized controlled trials. Burns. 2017 Feb;43(1):50-57. doi: 10.1016/j.burns.2016.07.004. Epub 2016 Aug 28. PMID: 27576926.
  3. Jonathan W. White. Honey. Advances in Food Research. 1978; 24. doi.org/10.1016/S0065-2628(08)60160-3.
  4. Moore OA, Smith LA, Campbell F, Seers K, McQuay HJ, Moore RA. Systematic review of the use of honey as a wound dressing. BMC Complement Altern Med. 2001;1:2. doi: 10.1186/1472-6882-1-2. Epub 2001 Jun 4. PMID: 11405898; PMCID: PMC32305.
  5. Banati A, Chowdhury SR, Mazumder S. Topical use of Sucralfate Cream in second and third degree burns. Burns. 2001 Aug;27(5):465-9.
  6. Godhi AS, Ram P, Powar R. Efficacy of topical sucralfate vERSUs silver sulfadiazine in the management of burns: A 1-year randomized controlled trial. J West Afr Coll Surg. 2017 Jan-Mar;7(1):57-70. PMID: 29951455; PMCID: PMC6018035.
  7. Koshariya, Mahim et al. “Role of topical Sucralfate in healing of burn wounds.” International Surgery Journal (2018): n. pag.
  8. Subrahmanyam M. A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Burns. 1998 Mar;24(2):157-61. doi: 10.1016/s0305-4179(97)00113-7. PMID: 9625243.
  9. Subrahmanyam M. Topical application of honey in treatment of burns. Br J Surg. 1991 Apr;78(4):497-8. doi: 10.1002/bjs.1800780435. PMID: 2032114.
  10. Subrahmanyam M. Honey impregnated gauze versus polyurethane film (OpSite) in the treatment of burns--a prospective randomised study. Br J Plast Surg. 1993 Jun;46(4):322-3. doi: 10.1016/0007-1226(93)90012-z. PMID: 8330089.
  11. Baghel PS, Shukla S, Mathur RK, Randa R. A comparative study to evaluate the effect of honey dressing and silver sulfadiazene dressing on wound healing in burn patients. Indian J Plast Surg. 2009 Jul;42(2):176-81. doi: 10.4103/0970-0358.59276. PMID: 20368852; PMCID: PMC2845359.
  12. Malik KI, Malik MA, Aslam A. Honey compared with silver sulphadiazine in the treatment of superficial partial-thickness burns. Int Wound J. 2010 Oct;7(5):413-7. doi: 10.1111/j.1742-481X.2010.00717.x. PMID: 20649832; PMCID: PMC7951523
PDF

Keywords

  • Sucralfate
  • Honey
  • Burns
  • Wound Healing

Author Information

Aditya Wardhana

Department of Surgery Ciptomangunkusumo Hospital, Jakarta, Indonesia, Indonesia.

Email: aditya_wrdn@yahoo.com

Nadya Farhana

Department of Surgery Ciptomangunkusumo Hospital, Jakarta, Indonesia, Indonesia.

Email: nfnadyafarhana@gmail.com

ORCID : https://orcid.org/0000-0002-2332-9808

Article History

Submitted : 3 January 2025
Revised : 3 January 2025
Published : 6 March 2024

How to Cite This

Wardhana, A., & Farhana, N. (2024). Sucralfate and Honey in Burn Wound Healing: An Article Review. Jurnal Plastik Rekonstruksi, 11(1), 22–27. https://doi.org/10.14228/jprjournal.v11i1.371

Crossmark and Dimension

Verify authenticity via CrossMark

Share This Article

Copyright & License

Authors retain the copyright of the article and grant Jurnal Plastik Rekonstruksi the right of first publication with the work simultaneously licensed under a Creative Commons Attribution License. Articles opting for open access will be immediately available and permanently free for everyone to read, download and share from the time of publication.

This work is licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Open Access Statement

Jurnal Plastik Rekonstruksi is an open access journal. This journal provides immediate open access to every article on the principle that making research freely accessible to the public; It supports a greater global exchange of knowledge; and an invaluable way to boost the visibility and impact of research.

This also means that Jurnal Plastik Rekonstruksi it's free availability on the public Internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than that inseparable from gaining access to the Internet itself.

Journal Info

Profile Image
Editor-in-Chief: dr. Narottama Tunjung, Sp.B.P.R.E., F.L.
Frequency: 2 issues per year (March & September)
National Accreditation: Sinta 3
Email: info@jprjournal.com

Video Article

Multistages Aesthetic Refinement Post Anterolateral Thigh Free Flap in Head and Neck Reconstruction

Atmodiwirjo P, Ramadan MR, Triatmoko SE, Arina MN. Multistages Aesthetic Refinement Post Anterolateral Thigh Free Flap in Head and Neck Reconstruction. J Plast Rekons 2020;7(1):38-42. DOI: https://doi.org/10.14228/jpr.v7i1.298

How to Harvest The Radial Forearm Free Flap

Atmodiwirjo P, Ramadan MR, Triatmoko SE, Ralena NA. How to Harvest Radial Forearm Free Flap. J Plast Rekons 2020;7(1):7-9. DOI: https://doi.org/10.14228/jpr.v7i1.296  

ACCREDITATION

Since October 2020, Jurnal Plastik Rekonstruksi has received Accreditation from the Ministry of Technology Research / National Research and Innovation Agency (SINTA 3)

https://sinta.ristekbrin.go.id/journals/detail?id=2054

Indexed by:

   

.    

custom_header

ISSN : 2089-6492
Online ISSN : 2089-9734
Publisher: The Lingkar Studi Bedah Plastik Foundation and is the official journal of Plastic Reconstructive and Aesthetic Surgery Residency Program, Faculty of Medicine, Universitas Indonesia.

Current Issue