Published : 15 February 2025

Analyzing The Efficacy and Outcome of Amniotic Membrane in Burn Care: A Systematic Review and Meta-Analysis

  • Nandita Melati Putri
  • Aditya Wardhana
  • Normalina Sandora
  • Akhmad Noviandi Syarif
  • Nadya Farhana
  • Sheila Oklia

Volume 12, Issue 1, (2025): Jurnal Plastik Rekonstruksi | Pages : 14-29

DOI: 10.14228/jprjournal.v12i1.384   Reader : 131 times PDF Download : 25 times

Abstract

Introduction: Managing burn injuries is a significant clinical challenge in promoting wound healing and minimizing complications. Advances like amniotic membrane as a biological dressing have been introduced to improve wound healing. This study analyzes the efficacy of amniotic membrane in burn care and its impact on wound healing outcomes.
Methods: We conducted a systematic review in Pubmed, Cochrane, and ScienceDirect, using “Amnion”, “Burns”, and “Wound healing” as keywords. The inclusion criteria are studies assessing the application of amniotic membrane on burn wounds. The outcome measures were mean healing time, wound healing rate, incidence of wound infection, dressing renewal frequency, pain score, and LOS.
Results: We identified eleven trials (n=971) ranging from the year 1989 to 2023, containing eight RCTs, and three NRCTs. The pooled RR showed statistically significant differences between amniotic membrane group and control group in mean healing time (RR -4.52 [95% CI; -6.93, -2.11]; p=0.0002), wound healing rate (RR 1.60 [95% CI; 1.09, 2.33]; p=0.02), incidence of wound infection (RR 0.48 [95% CI; 0.30, 0.77]; p=0.002), and dressing renewal frequency (RR -1.64 [95% CI; -2.48, -0.79]; p=0.0002).
Conclusion: This meta-analysis indicates that amniotic membrane is advantageous as a biological dressing for burn patients.

Data Availability

All data generated during this study are included in this published article [and its supplementary information files].

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Keywords

  • Amniotic Membrane
  • Burns
  • Dressing Renewal Frequency
  • Incidence of Wound Infection
  • Length of Hospital Stay
  • Mean Healing Time
  • Pain Score
  • Wound Healing Rate

Author Information

Nandita Melati Putri

Plastic Reconstructive and Aesthetic Department of Surgery, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia.

Email: nandita.putri@ui.ac.id

ORCID : https://orcid.org/0000-0003-0839-7877

Aditya Wardhana

Plastic Reconstructive and Aesthetic Division, Department of Surgery, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta,, Indonesia.

Email: aditya_wrdn@yahoo.com

ORCID : https://orcid.org/0000-0002-7577-8357

Normalina Sandora

Indonesia Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia.

Email: normalinasandora@gmail.com

ORCID : https://orcid.org/0000-0002-2332-9605

Akhmad Noviandi Syarif

Plastic Reconstructive and Aesthetic Division, Department of Surgery, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta,, Indonesia.

Email: akhmad.noviandi01@ui.ac.id

ORCID : https://orcid.org/0000-0001-9708-8915

Nadya Farhana

Plastic Reconstructive and Aesthetic Division, Department of Surgery, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia.

Email: nfnadyafarhana@gmail.com

ORCID : https://orcid.org/0000-0002-2332-9808

Sheila Oklia

Plastic Reconstructive and Aesthetic Division, Department of Surgery, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia.

Email: sheilaokliaa@gmail.com

ORCID : https://orcid.org/0009-0005-8712-5600

Article History

Submitted : 3 February 2025
Revised : 3 February 2025
Published : 15 February 2025

How to Cite This

Putri, N. M., Wardhana, A., Sandora, N., Syarif, A. N., Farhana, N., & Oklia, S. (2025). Analyzing The Efficacy and Outcome of Amniotic Membrane in Burn Care: A Systematic Review and Meta-Analysis. Jurnal Plastik Rekonstruksi, 12(1), 14–29. https://doi.org/10.14228/jprjournal.v12i1.384

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