Main Article Content

Aditya Wardhana
Michelle Valeria


Summary: The concept of tissue engineering has now been accounted for one of the most prospective answers to the growing needs of tissue and organ replacements. Many studies and researches are continuously done to achieve a paramount strategy in tissue engineering and regenerative medicine. This review emphasizes the concept, strategies, current application, and current challenges in tissue engineering. The strategy in tissue engineering has much improved and successfully applied in several reconstructive cases. Understanding of isolated cells’ behaviors, materials suitable for its’ scaffolds, in adjuncts with specific growth-inducing factors for each specific tissue or organ built is the key for successful tissue engineering.

Ringkasan: Konsep tissue engineering merupakan salah satu jawaban yang paling diharapkan dapat memenuhi kebutuhan pengganti jaringan dan organ yang terus meningkat pada saat ini. Beragam studi dan penelitian secara terus-menerus dilakukan agar dapat memperoleh strategi terbaik dalam tissue engineering dan regenerative medicine. Artikel ini berfokus pada konsep, strategi, aplikasi terkini, dan tantangan di masa mendatang pada tissue engineering. Strategi tissue engineering telah banyak berkembangan dan berhasil diterapkan pada kasus-kasus rekonstruksi. Pemahaman mengenai perilaku sel, kecocokan material dengan scaffolds, serta faktor pendukung pertumbuhan untuk masing-masing jaringan atau organ spesifik yang akan diciptakan merupakan kunci keberhasian tissue engineering.


Metrics Loading ...

Article Details

How to Cite
Wardhana A, Valeria M. Tissue Engineering and Regenerative Medicine: A Review. J Plast Rekons [Internet]. 2020Apr.25 [cited 2020Aug.3];7(1):10-7. Available from:
1. Wong W.V., Rustad K.C., Longaker M.T., Gurtner G.C. Tissue engineering in plastic surgery: A review. Plast Reconstr Surg. 2010; 126:858-68.
2. Horch R.E. New developments and trends in tissue engineering: An update. J Tissue Sci Eng. 2012;3(2):110-4.
3. Sterodimas A, Faria J.D., Correa W.E., Pitanguy I. Tissue engineering in plastic surgery; An up-to-date review of the current literature. Ann Plast Surg. 2009; 62:97-103.
4. Varkey M., Ding J., Tredget E.T. Advances in skin substitutes: Potential of tissue engineered skin for facilitating anti-fibrotic healing. J Funct Biomater. 2015;6(3):547-63.
5. Treiser M.D., Austen W.G. Concepts of tissue engineering. In: Chung K.C. Grabb and smith’s plastic surgery. 8th ed. Philadelphia: Wolters Kluwer; 2020:112-8.
6. Meyer U. The history of tissue engineering and regenerative medicine in perspective. In: Meyer U., Handschel J., Wiesmann H., Meyer T. Fundamentals of tissue engineering and regenerative medicine. Berlin: Springer; 2009:5-12.
7. Berthiaume F., Maguire T.J., Yarmush M.L. Tissue engineering and regenerative medicine: History, progress, and challenges. Annu. Rev. Chem. Biomol. Eng. 2011; 2:403-30.
8. Kementerian Kesehatan Republik Indonesia. Stem cell tak bebas dijualbelikan. Available at: Accessed April 8, 2020.
9. Future Medicine Unitec House. Sptolight on the shortlist: Ismail H. Dilogo’s lab, Universitas Indonesia. Available at: Accessed: April 8, 2020.
10. Dhamasana A., Singh S., Kadian S., Singh L. Skin tissue engineering: Principles and advances. J Dermatol Skin. 2018;1(1):1-11.
11. Vig K., Chaudhari A., Tripathi S. Dixit S., Sahu R., Pillai S., Dennis V.A., Singh S.R. Advances in skin regeneration using tissue engineering. Int J Mol Sci. 2017;18(4):789.
12. Chouhan D., Dey N., Bhardwaj N., Mandal B. Emerging and innovative approaches for wound healing and skin regeneration: Current status and advances. Biomaterials. 2019; 216:119267.
13. Vloemans A.F., Hermans M.H., van der Wal M.B., Liebregts J., Middelkoop E. Optimal treatment of partial thickness burns in children: A systematic review. Burns [Internet]. 2013 [cited 2020 Apr 6]. Available from:
14. Pham C., Greenwood J., Cleland H., Woodruff P., Maddern G. Bioengineered skin substitutes for management of burns: A systematic review. Burns. 2007; 33:946-57.
15. Hoogewerf C.J., Van Baar M.E., Hop M.J., Nieuwenhuis M.J., Oen I.M., Middelkoop E. Topical treatment for facial burns. Cochrane database of systematic reviews. 2013;1:CD008058.
16. Nicoletti G., Tresoldi M.M., Malovini A., Visaggio M., Faga A., Scevola S. Versatile use of dermal substitutes: A retrospective survey of 127 consecutive cases. Indian J Plast Surg. 2018;51(1):46-53.
17. Wardhana A., Liem I.K., Feroniasanti L., Pudjiti D.J., Mujadid F., Kispa T., Novialdi. Application of allo mesenchymal stem cells on chronic burn wound: Case series report. J Plast Rekons. 2017;4(1):68-72.
18. Stosich M.S., Mao J.J. Adipose tissue engineering from human adult stem cells: Clinical implications in plastic and reconstructive surgery. Plast Reconstr Surg. 2007;119(1):71-85.
19. Bashir M.M., Sohail M., Bashil A., Khan F.A., Jan S.N., Imran M., Ahmad F.J., Choudhery M.S. Outcome of conventional adipose tissue grafting for contour deformities of face and role of ex vivo expanded adipose tissue-derived stem cells in treatment of such deformities. J Craniofac Surg. 2018;29(5):1143-7.
20. Bigdeli N., Karlsson C., Strehl R., Concaro S., Hyllner J., Lindahl A. Coculture of human embryonic stem cells and human articular chondrocytes results in significantly altered phenotype and improved chondrogenic differentiation. Stem Cells. 2009;27:1812-21.
21. Dilogo I.H., Phedy P., Kholinne E., Djaja Y.P., Fiolin J., Kusnadi Y., Yulisa N.D. Autologous mesenchymal stem cell implantation, hydroxyapatite, bone morphogenetic protein-2, and internal fixation for treating critical-sized defects: a translational study. Int Orthop. 2019;43(6):1509-19.
22. Ismail H.D., Phedy, Kholinne E., Jusuf A.A., Yulisa N.D. Role of allogenic mesenchymal stem cells in the reconstruction of bone defects in rabbits. Med J Indones. 2014;23(1):9-14.